1. Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain in Mice

Reference

  • Duration: 20 days
  • Studies: Mice subjected to oxaliplatin-induced neuropathic pain
  • Findings: The study demonstrated that HRW consumption alleviated oxaliplatin-induced hyperalgesia in mice. The beneficial effects were associated with alterations in gut microbiota composition and a reduction in oxidative stress and inflammation.

2. Glioblastoma

Antitumoral Activity of Molecular Hydrogen in Glioblastoma Treatment

Reference

  • Studies: Animal models (mice) with glioblastoma
  • Findings: In vivo studies demonstrated that hydrogen inhalation effectively suppressed glioblastoma tumor growth, leading to prolonged survival in mice. Additionally, hydrogen treatment inhibited the migration, invasion, and colony-forming abilities of glioma cells.

3. Colorectal cancer cells

    a. Hydrogen-Rich Water Exerts Anti-Tumor Effects Comparable to 5-Fluorouracil

Reference

  • Duration: 14 days
  • Studies: Animal models (mice) implanted with colorectal cancer cells
  • Findings: The study found that hydrogen-rich water (HRW) demonstrated anti-cancer properties comparable to the chemotherapy drug 5-fluorouracil (5-FU). When combined with 5-FU, HRW synergistically suppressed tumor progression, improved oxidative stress markers, and reduced adverse effects.

    b. Protective Effect of Hydrogen-Rich Water on Liver Function in Colorectal Cancer Patients Undergoing Chemotherapy

Reference

  • Studies: 146 colorectal cancer patients undergoing mFOLFOX6 chemotherapy were included in the final analysis.
  • Findings: The study found that the HRW group exhibited no significant differences in liver function before and after treatment, whereas the placebo group showed significantly elevated levels of liver enzymes (ALT, AST, and IBIL) after chemotherapy. This suggests that HRW may alleviate chemotherapy-induced liver injury.

4. Breast cancer

Hydrogen -Rich Water Delays Mammary Tumor Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro

Reference

  • Duration: Not specified
  • Studies: In vitro: Human breast cancer cell lines (MCF-7, MDA-MB-453, TUBO); In vivo: Transgenic BALB-neuT mice
  • Findings: HRW treatment inhibited cell survival in a time-dependent manner, decreased ErbB2/neu expression, and impaired phosphorylation of ERK1/ERK2 and AKT in breast cancer cells. In vivo, HRW delayed mammary tumor development, prolonged tumor-free survival, and reduced tumor multiplicity in mice.

5. Gastric Cancer

Hydrogen Water and Gastric Cancer:

Reference

Studies: Hydrogen-rich water (HRW) reduced oxidative stress and inhibited the growth of gastric cancer cells. It also improved inflammation markers and enhanced the overall survival rate in mice. The study suggests that HRW may be a useful adjunctive therapy for gastric cancer by protecting cells from damage and promoting better outcomes.

6. Liver cancer

Study on Hydrogen-Rich Water for Nonalcoholic Steatohepatitis (NASH) and Hepatocarcinogenesis

Reference

  • Duration: 8 weeks
  • Studies: Mice on a methionine-choline-deficient (MCD) diet
  • Findings: Hydrogen-rich water (HRW) reduced oxidative stress, inflammatory markers, and apoptosis, resulting in improved liver function compared to control groups. It showed stronger antioxidant effects compared to pioglitazone. Additionally, HRW helped prevent the progression from NASH to hepatocarcinogenesis in mice.

Conclusion;

These studies suggest that whether administered as inhaled gas or in hydrogen-rich water, molecular hydrogen may have potential therapeutic effects against certain types of cancer and neurological conditions. However, further research, including well-designed clinical trials, is necessary to confirm these findings and determine the safety and efficacy of hydrogen-based therapies in humans.