A. Study Effects of Hydrogen-Rich Water on Inflammation and Cell Health

Reference

Participants: 26 healthy adults were randomly assigned to either a hydrogen-rich water or placebo group.
Findings:

  • Hydrogen-rich water reduced inflammatory responses.
  • It prevented apoptosis (cell death) of peripheral blood cells.
  • The study suggests potential benefits for immune system modulation and overall cellular health.

B. Study Protective Effects of Hydrogen-Rich Water Against NSAID-Induced Intestinal Damage

Reference

Study Participants: The research was conducted on animal models, specifically mice, to assess the impact of HRW on NSAID-induced enteropathy.

Findings:

  • Reduction of Oxidative Stress: HRW administration led to a significant decrease in reactive oxygen species (ROS) levels in the intestines, indicating reduced oxidative stress.
  • Preservation of Intestinal Integrity: Mice treated with HRW exhibited less intestinal damage than the control group, suggesting a protective effect on gut integrity.

Modulation of Gut Microbiota: HRW influenced the composition of gut bacteria, leading to an increase in the production of short-chain fatty acids (SCFAs), which are beneficial for intestinal health.

C. Study Effects of Hydrogen-Rich Water and Hydrogen Gas Inhalation on Gut Microbiome and Metabolism

Reference

Study Participants:

  • Conducted on healthy rats, divided into three groups:
    1. Control group
    2. Hydrogen-rich water (HRW) group
    3. Hydrogen gas inhalation (HI) group

Findings:

  • Plasma Metabolites:
    • HRW mainly influenced starch and sucrose metabolism.
    • HI primarily affected arginine biosynthesis.
  • Gut Microbiome Changes:
    • HRW decreased Lactobacillus, Ruminococcus, Clostridium XI, and Bacteroides.
    • HI reduced Blautia and Paraprevotella populations.
  • Metabolic Effects:
    • HI reduced voluntary food intake and excretion, while HRW had no significant impact.

The study highlights the distinct effects of HRW and HI on metabolism and gut bacteria in healthy rats.

D. Study Therapeutic Effects of Hydrogen-Rich Water in Inflammatory Bowel Disease

Reference

Study Participants:

  • The study was conducted on mice induced with inflammatory bowel disease (IBD) using dextran sulfate sodium (DSS).

Findings:

  • Reduction of Inflammation: HRW significantly reduced levels of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β).
  • Mitigation of Oxidative Stress: Decreased oxidative stress markers (MDA, MPO) and increased antioxidants (SOD, GSH).
  • Inhibition of Endoplasmic Reticulum Stress: Reduced ER stress markers (p-eIF2α, ATF4, XBP1s, CHOP).
  • Upregulation of Heme Oxygenase-1 (HO-1): HRW increased HO-1 expression, providing anti-inflammatory and antioxidant benefits.

These findings suggest that HRW can alleviate IBD by reducing inflammation, oxidative, and ER stress while promoting protective enzyme expression.

E. Study Molecular Hydrogen as a Potential Treatment for Sepsis

Reference

These studies provided us with these
Findings:

  • Antioxidant Properties: Hydrogen scavenges free radicals, reducing oxidative stress in sepsis.
  • Anti-Inflammatory Effects: It helps reduce inflammation and organ damage during sepsis.
  • Anti-Apoptotic Effects: Hydrogen inhibits apoptosis, preserving organ function.
  • Regulation of Autophagy: It influences autophagy, which can impact sepsis severity.

Potential Clinical Use: Hydrogen is considered a promising adjunctive therapy in sepsis management.